Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the concentration...
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracochlear PLGA implants for simultaneous controlled release of multiple drugs.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Release mechanisms of PLGA-based drug delivery systems: A review.

International journal of pharmaceutics: X·2025
Same author

Release mechanisms of PLGA microparticles prepared using a microfluidics device or a beaker.

International journal of pharmaceutics: X·2025
Same author

EVA implants for controlled drug delivery to the inner ear.

International journal of pharmaceutics: X·2024
Same author

In-situ forming PLGA implants: Towards less toxic solvents.

International journal of pharmaceutics·2024
Same author

Colon targeting in rats, dogs and IBD patients with species-independent film coatings.

International journal of pharmaceutics: X·2024

Related Experiment Video

Updated: May 12, 2026

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules
05:59

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules

Published on: November 4, 2022

Mathematical modeling of drug dissolution.

J Siepmann1, F Siepmann

  • 1University of Lille, College of Pharmacy, 3 Rue du Prof. Laguesse, 59006 Lille, France. juergen.siepmann@univ-lille2.fr

International Journal of Pharmaceutics
|April 27, 2013
PubMed
Summary

Drug dissolution is essential for bioavailability and therapeutic efficacy. Understanding dissolution kinetics, especially for poorly soluble drugs, is key to successful treatments and optimized drug delivery systems.

Keywords:
DiffusionDrug dissolutionHixson–Crowell equationMathematical modelingNernst–Brunner equationNoyes–Whitney equation

More Related Videos

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
08:59

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

Published on: January 14, 2020

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
09:59

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Published on: July 4, 2014

Related Experiment Videos

Last Updated: May 12, 2026

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules
05:59

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules

Published on: November 4, 2022

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
08:59

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

Published on: January 14, 2020

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
09:59

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Published on: July 4, 2014

Area of Science:

  • Pharmaceutical Sciences
  • Physical Chemistry
  • Biopharmaceutics

Background:

  • Drug dissolution is a critical prerequisite for absorption and therapeutic efficacy.
  • Poor solubility and low dissolution rates can lead to treatment failure.
  • Dissolution involves complex physical processes like wetting, solvation, and diffusion.

Purpose of the Study:

  • To provide an overview of the state-of-the-art in modeling drug dissolution.
  • To discuss the assumptions underlying various dissolution theories.
  • To illustrate the practical benefits of dissolution modeling with examples.

Main Methods:

  • Review of mathematical equations and theories describing drug dissolution kinetics.
  • Analysis of physical phenomena involved in drug dissolution.
  • Examination of models for both immediate and controlled-release drug products.

Main Results:

  • Mathematical models can quantify mass transport steps in drug dissolution.
  • Various theories describe drug dissolution kinetics with different assumptions.
  • Models are applicable to drugs with poor solubility and controlled-release formulations.

Conclusions:

  • Accurate modeling of drug dissolution is crucial for predicting in vivo performance.
  • Understanding dissolution kinetics enhances drug development and formulation design.
  • Modeling benefits include optimizing bioavailability and therapeutic outcomes for diverse drug types.