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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Interface dermatitis.

Rajiv Joshi1

  • 1Department of Dermatology and Dermato Pathology, P D Hinduja Hospital, Mumbai, Maharashtra, India.

Indian Journal of Dermatology, Venereology and Leprology
|April 27, 2013
PubMed
Summary
This summary is machine-generated.

Interface dermatitis involves damage to the dermo-epidermal junction, characterized by specific histological findings. Differential diagnoses rely on secondary epidermal and dermal changes, along with inflammatory cell patterns.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Interface dermatitis encompasses a group of skin diseases primarily affecting the dermo-epidermal junction.
  • Key histological features include basal cell vacuolization, apoptotic keratinocytes (colloid or Civatte bodies), and inflammatory cell infiltration obscuring the junction.

Purpose of the Study:

  • To elucidate the histological hallmarks of interface dermatitis.
  • To outline the diagnostic criteria for differentiating various interface dermatoses.

Main Methods:

  • Histopathological examination of skin biopsies.
  • Analysis of secondary epidermal and papillary dermal changes.
  • Evaluation of inflammatory cell type, distribution, and density.

Main Results:

  • Specific histological findings are characteristic of interface dermatitis.
  • Differential diagnoses are established by assessing secondary changes and inflammatory infiltrates.
  • Major interface diseases include lupus erythematosus, dermatomyositis, lichen planus, graft-versus-host disease, erythema multiforme, fixed drug eruptions, lichen striatus, and pityriasis lichenoides.

Conclusions:

  • Interface dermatitis is defined by characteristic histopathological changes at the dermo-epidermal junction.
  • A systematic approach to histological analysis aids in diagnosing specific interface dermatoses.
  • Other inflammatory, infectious, and neoplastic conditions can also present with interface changes.