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Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
Hyperhomocysteinia is a risk factor for retinal venous occlusion: a case control study
Fahad Al Wadani, Rajiv Khandekar1, Gigani Salim
1Eye and Ear Health Care, Deaprtment of Non communicable Diseases control, Ministry of Health, Muscat, Oman.
Indian Journal of Ophthalmology
|April 27, 2013
Summary
Hyperhomocysteinemia significantly increases the risk of retinal vein occlusion (RVO) in Indian patients. Measuring total plasma homocysteine levels is recommended for RVO diagnosis.
Area of Science:
- Ophthalmology
- Cardiovascular Research
- Metabolic Disorders
Background:
- Retinal vein occlusion (RVO) is a significant cause of vision loss.
- The role of hyperhomocysteinemia as a risk factor for RVO in the Indian population requires further investigation.
Purpose of the Study:
- To evaluate the association between hyperhomocysteinemia and the risk of developing RVO in Indian patients.
- To determine if elevated homocysteine levels are a predictive factor for RVO.
Main Methods:
- A matched case-control study was conducted between 2006 and 2007.
- Serum and urine homocysteine levels were measured in 20 RVO cases and 20 matched controls.
- Matched pair analysis was employed to assess the risk associated with hyperhomocysteinemia.
Main Results:
- A significantly higher risk of RVO was observed in individuals with hyperhomocysteinemia (mean difference 31.62 μmol/L, P = 2.1 × 10-13).
- No statistically significant difference in mean urine homocysteine levels was found between cases and controls.
- Hypertension prevalence was similar in both RVO cases and control groups (12 individuals each).
Conclusions:
- Hyperhomocysteinemia is confirmed as a significant risk factor for RVO.
- Total plasma homocysteine (tHcy) level measurement should be a routine investigation for patients presenting with RVO.
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