Related Experiment Video
Updated: May 11, 2026
Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
Published on: September 27, 2021
Clinical evaluation and feasibility of changing intraoperative visibility with a novel viewing filter system for
Hiroshi Enaida1, Yasuhiro Ikeda, Shigeo Yoshida
1*Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka, Japan; †Department of Technology & Development, Hoya Corporation Medical Division, Funado, Itabashi-ku, Tokyo, Japan; ‡Department of Ophthalmology, Osaka University Medical School, Yamadaoka, Suita, Osaka, Japan; §Department of Ophthalmology, Yokohama City University Medical Center, Urafune-cho, Minami-ku, Yokohama, Japan; ¶Ohshima Hospital of Ophthalmology, Kamigofuku-machi, Hakata-ku, Fukuoka, Japan.
Purpose:
The study was conducted to develop a new viewing system as a clinical prototype that enables visibility during surgery.
Methods:
The system was composed of several filters attached to the microscope. This nonrandomized, retrospective, observational case series study involved 33 eyes from 32 patients who presented with various diseases and underwent surgery. The authors evaluated the changes in visualization focusing on controlling intraoperative visibility under air infusion and enhancing Brilliant Blue G staining focusing a sharp-cut filter Y (SCY). Visibility was compared under various surgical conditions, including cataract surgery, both with and without this system. Quantitative analysis of changes in intraoperative reflection including halation under air infusion and Brilliant Blue G intensity was carried out using the International Commission on Illumination 1976 (L*, a*, b*) color space method.
Results:
A SCY reduced the reflection and halation by a maximum of 69.6%, when compared with use of no filter under air infusion (P < 0.01). The color difference between Brilliant Blue G-stained and nonstained areas was improved by 127.8% relative to values with no filter and using SCY (P < 0.01) in macular hole cases. Furthermore, in cataract surgery with corneal opacity, improvement of visibility was observed by SCY insertion.
Conclusion:
The system improved intraoperative visibility under air infusion and the Brilliant Blue G staining intensity by use of SCY during vitrectomy.
