Related Experiment Video
Updated: May 11, 2026

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
Published on: September 10, 2018
Response to comment on "In monkeys making value-based decisions, LIP neurons encode cue salience and not action
Marvin L Leathers1, Carl R Olson
1Center for the Neural Basis of Cognition, Carnegie Mellon University, Mellon Institute, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.
Abstract:
Newsome et al. question neither our key result, that large-penalty cues elicited stronger responses than small-penalty cues, nor our key conclusion, that neurons early in the trial signaled cue salience and not action value. Instead, they focus on subsequent neuronal activity. The patterns of delay-period activity that they note can be explained by reference to experimental methodology.
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