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Related Experiment Videos

Fertilization failure in IVF: why and what next?

P Barlow1, Y Englert, F Puissant

  • 1IVF Clinic and Human Reproduction Research Unit, Saint Pierre Hospital, Free University Brussels, Belgium.

Human Reproduction (Oxford, England)
|May 1, 1990
PubMed
Summary

Total fertilization failure (FF) in IVF is higher with severe sperm defects. Fertilization rate (FR) correlates with sperm quality and oocyte count, but not female factors or age. Recurrent FF impacts pregnancy success.

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Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)
  • Spermatozoa Analysis

Background:

  • Total fertilization failure (FF) is a significant concern in assisted reproductive technologies.
  • Understanding factors influencing FF and fertilization rate (FR) is crucial for optimizing IVF outcomes.
  • Sperm quality is a key determinant in successful fertilization.

Purpose of the Study:

  • To investigate the relationship between sperm parameters and total fertilization failure (FF) in IVF.
  • To identify factors affecting fertilization rate (FR) per oocyte.
  • To explore the impact of female infertility causes and ovulation induction protocols on IVF success.

Main Methods:

  • Analysis of 587 oocyte collection procedures from 297 couples undergoing IVF.

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  • Categorization of sperm defects into normal, mild, moderate, and severe.
  • Correlation analysis of FF and FR with sperm count, motility, oocyte yield, female factors, and ovulation induction methods.

    • Main Results:

    • FF rate was significantly higher (26.5%) in cases with moderate to severe sperm defects compared to normal/mild defects (13.7-16.2%).
    • Fertilization rate (FR) correlated positively with sperm count and motility, and inversely with oocyte number retrieved.
    • Lower FR and higher FF were observed with spontaneous LH peak supplemented with HCG compared to HCG alone; female factors impacted FR in donor sperm cycles.

    Conclusions:

    • Sperm quality is a critical factor influencing total fertilization failure and fertilization rates in IVF.
    • Oocyte yield and ovulation induction protocols also play a role in IVF success.
    • Recurrent FF, particularly with suboptimal sperm parameters, is associated with a low probability of pregnancy.