Neutrophil-to-lymphocyte ratio predicts contrast-induced nephropathy in patients undergoing primary percutaneous...

Area of Science:

• Cardiology
• Nephrology
• Biomarkers

Background:

• Contrast-induced nephropathy (CIN) is a complication following percutaneous coronary intervention (PCI).
• Predictive markers for CIN in ST-segment elevation myocardial infarction (STEMI) patients are crucial for risk stratification.
• Neutrophil-to-lymphocyte ratio (NLR) is an accessible inflammatory marker.

Purpose of the Study:

• To investigate the association between baseline neutrophil-to-lymphocyte ratio (NLR) and the incidence of contrast-induced nephropathy (CIN).
• To identify predictors of CIN in patients with STEMI undergoing primary PCI.

Main Methods:

• Retrospective analysis of 691 consecutive STEMI patients undergoing primary PCI.
• CIN defined as a ≥25% increase in serum creatinine at 48 hours post-procedure.
• Statistical analysis to identify independent predictors of CIN, including NLR, C-reactive protein, and clinical factors.

Main Results:

• NLR and C-reactive protein levels were significantly higher in patients who developed CIN.
• Independent predictors of CIN included advanced age, diabetes mellitus (DM), low baseline glomerular filtration rate, reduced ST resolution, high contrast volume, high NLR, and low left ventricular ejection fraction.
• A stronger correlation between NLR and CIN was observed in patients with pre-existing chronic kidney disease and diabetes mellitus.

Conclusions:

• Baseline NLR is a simple, reliable, and independent predictor of CIN in STEMI patients undergoing primary PCI.
• NLR can aid in identifying patients at higher risk for CIN, facilitating timely intervention.
• Further research may explore the mechanistic link between inflammation, NLR, and CIN development.