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5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
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Published on: April 4, 2025

Type 2 translational research for CKD.

Katherine R Tuttle1, Delphine S Tuot, Cynthia L Corbett

  • 1Providence Medical Research Center, Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington; , †Nephrology Division, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;, ‡Division of Nephrology and , ¶Department of Medicine, University of California San Francisco, San Francisco, California, §College of Nursing and , ‖College of Pharmacy, Washington State University, Spokane, Washington.

Clinical Journal of the American Society of Nephrology : CJASN
|April 27, 2013
PubMed
Summary
This summary is machine-generated.

Type 2 translation research is crucial for implementing evidence-based treatments for chronic kidney disease (CKD). Integrating key facilitators and essential elements can improve CKD care and patient outcomes.

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Last Updated: May 11, 2026

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05:34

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Published on: April 4, 2025

Area of Science:

  • Nephrology
  • Translational Science
  • Public Health

Background:

  • Conventional clinical research has identified effective chronic kidney disease (CKD) treatments, yet their implementation remains suboptimal.
  • There is a critical need to translate clinical evidence into practical strategies to alleviate the burden of CKD.
  • Type 2 translation research expands beyond the 'bench-to-bedside' model to integrate 'clinic and community' settings.

Purpose of the Study:

  • To identify key elements and facilitators for type 2 translational research in CKD.
  • To highlight the current scope and urgent need for type 2 translation in CKD care.
  • To propose strategies for improving the adoption, maintenance, and sustainability of evidence-based CKD interventions.

Main Methods:

  • Review of type 2 translational research principles and their application to CKD.
  • Identification of facilitators (e.g., theory-based frameworks, adaptable interventions, sustainability metrics) and essential elements (e.g., multidisciplinary teams, health IT, stakeholder engagement).
  • Discussion of recent funding initiatives by the National Institute of Diabetes and Digestive and Kidney Diseases for CKD outcome improvement.

Main Results:

  • Type 2 translation requires integrating facilitators like adaptable interventions and essential elements such as multidisciplinary care and stakeholder engagement for successful implementation.
  • Recent funding supports diverse CKD research across the healthcare continuum, aiming to improve patient safety, care delivery, and reduce disparities.
  • The urgency for type 2 translation in CKD is driven by preventable suffering and high care costs.

Conclusions:

  • Type 2 translational research is essential for bridging the gap between CKD evidence and practice.
  • Integrating proposed theories, frameworks, and approaches can enhance the effectiveness and sustainability of CKD interventions.
  • Focusing on type 2 translation is vital for achieving high-quality CKD care and better health outcomes, ultimately reducing the human and economic costs of the disease.