Related Experiment Video
Updated: May 11, 2026

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
Published on: April 12, 2019
Stability of DNA nanostructures by junction penalty
1Department of Chemical Engineering, University of Seoul, Seoulsiripdaero 163, Dongdaemun-gu, Seoul 130-743, Republic of Korea. JBLEE@uos.ac.kr
Abstract:
DNA nanostructures have been attracting much attention because of their well-controlled nanoarchitectural features. However, regulating the stability of DNA nanostructures is less well understood because of complexity. In this paper, the stability of DNA nanostructure was studied first in the form of simple building blocks. Since these DNA nanostructures have junctions on the center of the structures, the junctions were mainly investigated as a factor in the instability. In addition, regulation of the stability of complicated nanostructures based on these building blocks was achieved. Förster resonance energy transfer (FRET) methods were employed to monitor the conformation change with nano-scale sensitivity. The junction effect on DNA nanostructures was monitored with labeling FRET pairs at various conditions. DNA tile structures was also thoroughly studied by FRET.
Related Concept Videos
Single-Strand DNA Binding Proteins
DNA Damage can Stall the Cell Cycle
RNA Stability
DNA Topoisomerases
Types and Mechanism of action
Topoisomerases are divided into two main types. Type I...
Fixing Double-strand Breaks
Overview of DNA Repair
Chemically...

