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Granulocyte transfusion therapy in paediatric patients with severe neutropenic infection

Seda Oztürkmen1, Fevzi Altuntaş, Lale Olcay

  • 1Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital of the Ministry of Health, Department of Pediatric Hematology, Ankara, Turkey. sedaozturkmen@yahoo.com

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|April 30, 2013
PubMed

Insights

Granulocyte transfusions (GTs) improved neutrophil and platelet counts in children with febrile neutropenia and severe infections. While generally well-tolerated, GTs showed potential benefits in this high-risk pediatric group.

Area of Science:

  • Pediatric Hematology
  • Infectious Diseases
  • Transfusion Medicine

Background:

  • Febrile neutropenia is a serious complication in children undergoing treatment for hematologic disorders.
  • Severe infections in neutropenic patients carry a high risk of mortality.
  • Limited treatment options exist for managing severe infections during neutropenia.

Purpose of the Study:

  • To retrospectively investigate the efficacy and safety of granulocyte transfusions (GTs) in pediatric patients with high-risk febrile neutropenia and severe infection.
  • To assess the impact of GTs on neutrophil and platelet counts.
  • To evaluate clinical response, hematologic response, and infection-related mortality.

Main Methods:

  • Retrospective analysis of data from 10 pediatric patients.
  • Patients received granulocyte transfusions (GTs) for high-risk febrile neutropenia with/without documented severe infection.
  • Evaluated pre- and post-transfusion hematologic counts, clinical outcomes, and adverse events.

Main Results:

  • Significant increases in 24-hour post-transfusion neutrophil (p=0.034) and platelet (p=0.025) counts were observed.
  • Clinical response rate was 69.2%, with a hematologic response rate of 53.8%.
  • Infection-related mortality was 30.8%; GTs were generally well-tolerated, with transient adverse events in three instances.

Conclusions:

  • Granulocyte transfusions (GTs) appear beneficial for children experiencing severe sepsis during neutropenia.
  • GTs can improve hematologic parameters and clinical outcomes in this vulnerable pediatric population.
  • Further research with larger cohorts is warranted to confirm the efficacy and safety of GTs.

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