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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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Published on: October 7, 2025

MicroRNAs in hematological malignancies.

Charles H Lawrie1

  • 1Biodonostia Research Institute, San Sebastián, Spain. charles.lawrie@ndcls.ox.ac.uk

Blood Reviews
|April 30, 2013
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are short, non-coding RNAs regulating gene control. This review explores their role in hematological malignancies and normal hematopoiesis, highlighting their potential as biomarkers and therapeutics.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are short, non-coding RNA molecules.
  • They have emerged as critical regulators of gene expression.
  • Their role in physiological and pathological processes is increasingly recognized.

Purpose of the Study:

  • To review the function of miRNAs in normal hematopoiesis.
  • To explore the role and clinical utility of miRNAs in hematological malignancies.
  • To discuss miRNAs as potential biomarkers and therapeutic agents.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of existing research on miRNA function.
  • Synthesis of data on miRNA involvement in blood disorders.

Main Results:

  • miRNAs play a crucial regulatory role in gene expression.
  • They are implicated in both normal blood cell development and blood cancers.
  • The field of miRNA research is rapidly advancing.

Conclusions:

  • miRNAs offer novel insights into hematological processes.
  • They hold significant promise as diagnostic biomarkers for hematological malignancies.
  • miRNAs represent a potential new class of therapeutics for blood cancers.