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Updated: May 11, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
Roles for central leptin receptors in the control of meal size
Gary J Schwartz1, Anthony V Azzara, Martica K Heaner
1Departments of Medicine & Neuroscience, Albert Einstein College of Medicine, Diabetes Research and Training Center, New York Obesity Research Center, USA.
Abstract:
The adiposity hormone leptin has been implicated in the regulation of behavioral and metabolic controls of body weight. Leptin receptors are found in multiple peripheral and central tissues, particularly within hypothalamic and brainstem neuronal populations. Central leptinergic signaling acts as an indirect control to modulate the feeding inhibitory potency of the direct controls of meal size. Mouse models of neuronal leptin loss and gain of function have helped to identify and characterize how central leptin contributes to the central control of food intake.
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