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Related Experiment Video

Updated: May 11, 2026

Preparation of Formalin-fixed Paraffin-embedded Tissue Cores for both RNA and DNA Extraction
08:30

Preparation of Formalin-fixed Paraffin-embedded Tissue Cores for both RNA and DNA Extraction

Published on: August 21, 2016

Tissue sample preparation for biomarker discovery.

Yoshiyuki Suehara1, Daisuke Kubota, Tsuyoshi Saito

  • 1Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan.

Methods in Molecular Biology (Clifton, N.J.)
|April 30, 2013
PubMed
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Proteomics, the study of global protein expression, reveals tumor biology insights. These studies generate protein profiles crucial for discovering novel diagnostic and therapeutic tumor biomarkers.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Global protein expression profiling, or proteomics, offers unique insights into tumor biology.
  • Proteomic studies generate comprehensive protein expression profiles of tumors.
  • These profiles are essential for identifying novel biomarkers.

Purpose of the Study:

  • To outline the strategy and design of proteomic studies for biomarker discovery.
  • To detail protocols for tissue sample collection and preparation.
  • To present examples of recent proteomic studies focused on tumor biomarkers.

Main Methods:

  • Proteomic analysis of tumor tissues.
  • Development of protocols for sample handling and preparation.
  • Bioinformatic analysis of protein expression data.

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A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
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A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Related Experiment Videos

Last Updated: May 11, 2026

Preparation of Formalin-fixed Paraffin-embedded Tissue Cores for both RNA and DNA Extraction
08:30

Preparation of Formalin-fixed Paraffin-embedded Tissue Cores for both RNA and DNA Extraction

Published on: August 21, 2016

Proteomic Sample Preparation from Formalin Fixed and Paraffin Embedded Tissue
09:20

Proteomic Sample Preparation from Formalin Fixed and Paraffin Embedded Tissue

Published on: September 2, 2013

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Main Results:

  • Established methodologies for proteomic studies in oncology.
  • Identified potential protein expression signatures for tumor characterization.
  • Demonstrated the utility of proteomics in biomarker discovery.

Conclusions:

  • Proteomics is a powerful approach for understanding tumor biology.
  • Standardized protocols enhance the reliability of proteomic biomarker discovery.
  • This work provides a foundation for developing new cancer diagnostics and therapeutics.