Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pressure within the thoracic duct modulates lymph composition.

J R Elk1, G A Laine

  • 1Center for Microvascular and Lymphatic Studies, University of Texas Medical School, Houston 77030.

Microvascular Research
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the effects of immediate application of negative pressure therapy after decompression from abdominal compartment syndrome in an experimental porcine model.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2016
Same author

Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps.

American journal of physiology. Regulatory, integrative and comparative physiology·2014
Same author

Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure.

American journal of physiology. Heart and circulatory physiology·2013
Same author

Decreased myosin phosphatase target subunit 1(MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle.

Neurogastroenterology and motility·2012
Same author

Evaluation of gravimetric techniques to estimate the microvascular filtration coefficient.

American journal of physiology. Regulatory, integrative and comparative physiology·2011
Same author

A murine model for the study of edema induced intestinal contractile dysfunction.

Neurogastroenterology and motility·2010
Same journal

Association between retinal microcirculation and cardiac function: A cross-sectional study using OCTA.

Microvascular research·2026
Same journal

Microvascular dysfunction and neurovascular signalling impairment in diabetic silent myocardial ischemia.

Microvascular research·2026
Same journal

Association of circulating biomarkers of glycocalyx injury, sirtuin 1, and NFκB p65 in individuals with type 2 diabetes and concurrent arterial hypertension.

Microvascular research·2026
Same journal

Targeting miR-10 alleviates atherosclerosis by enhancing intestinal ABCA1-mediated cholesterol efflux and repairing intestinal barrier.

Microvascular research·2026
Same journal

The effect of acute high-intensity interval exercise on microvascular function and local skeletal muscle oxygenation.

Microvascular research·2026
Same journal

RNF213 deficiency in human iPSC-derived vascular organoids captures key feature of moyamoya disease vasculopathy.

Microvascular research·2026
See all related articles

Altering thoracic duct pressure changes the source of lymph flow. Increased pressure reduces gut lymph contribution while enhancing liver lymph contribution, affecting overall fluid balance.

Area of Science:

  • Physiology
  • Lymphatic System Dynamics
  • Fluid Balance

Background:

  • Thoracic duct receives lymph from various organs, influenced by interstitial fluid production and pressure gradients.
  • Previous research suggests thoracic duct pressure can modify organ contributions to lymph flow.

Purpose of the Study:

  • To investigate how altering thoracic duct pressure affects the proportional contribution of lymph from different organs (liver, gut, lower body).

Main Methods:

  • Cannulation of the thoracic duct above the diaphragm in experimental subjects.
  • Serial elevation of thoracic duct pressure by adjusting lymphatic cannula outflow height.
  • Measurement of lymph protein concentration and chyle concentration (absorbance) to assess organ contributions.

Related Experiment Videos

Main Results:

  • Increasing thoracic duct pressure led to a higher lymph protein concentration, indicating increased liver lymph contribution.
  • Elevated thoracic duct pressure resulted in decreased chyle concentration, signifying a reduced gut lymph contribution.
  • The data demonstrate a direct relationship between thoracic duct pressure and the relative contributions of liver and gut lymph flow.

Conclusions:

  • Thoracic duct pressure is a critical factor regulating the volume and origin of lymph entering the central circulation.
  • Manipulating central lymphatic pressure can alter the distribution of lymph flow from different body regions, impacting fluid and edema management.