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Secondary membranous nephropathy associated with guillain-barré syndrome

Edward J Filippone1, Mitul Kanzaria, Rodney Bell

  • 1Department of Medicine, Thomas Jefferson University, Philadelphia, Pa., USA ; Division of Nephrology, Thomas Jefferson University, Philadelphia, Pa., USA.

Case Reports in Nephrology and Urology
|April 30, 2013
PubMed

Insights

Membranous nephropathy (MN), a common cause of nephrotic syndrome (NS), can be secondary to Guillain-Barré syndrome (GBS). This case suggests GBS may cause MN, highlighting a potential link between these conditions.

Area of Science:

  • Nephrology
  • Neurology
  • Immunology

Background:

  • Membranous nephropathy (MN) is a leading cause of nephrotic syndrome (NS) in adults.
  • MN can be primary (often IgG4-related) or secondary to other conditions.
  • Guillain-Barré syndrome (GBS) has been anecdotally linked to MN, but causality is unproven.

Observation:

  • This report details a patient who developed GBS and severe NS concurrently.
  • Renal biopsy confirmed membranous nephropathy (MN).
  • Immunohistochemical staining for IgG4 was negative.

Findings:

  • The absence of IgG4 staining suggests the MN was secondary, not primary.
  • The concurrent presentation strongly implies GBS as the probable cause of MN in this case.

Implications:

  • This case provides evidence for a potential causal relationship between GBS and MN.
  • Understanding this association may improve diagnosis and management of patients with both conditions.
  • Further research is warranted to elucidate the mechanisms linking GBS and MN.
Keywords:
Guillain-Barré syndromeMembranous nephropathyNephrotic syndrome

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