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Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
Published on: January 19, 2020
[Technical study of vinpocetine micelles prepared by thin-film hydration method]
Zhi-Jun Huang1, Tao Li, Xiao-Juan Guo
1Department of Pharmacology, Guangdong General Hospital, Guangzhou 510080, China. zhijunh517@126.com
Objective:
To prepare PEG-PLA polymeric micelles loaded with vinpocetine (VP).
Methods:
VP micelles were prepared by thin-film hydration method, single factors affecting drug loading content, encapsulation efficiency, productivity, particle size and polydispersity index (PDI) such as dosage, type of organic solvent, quantity of organic solvent, hydration temperature, hydration speed, amount of hydration water, hydration time were investigated, and the optimum technology was obtained. The mean particle size and PDI were determined by DLS. The drug loading content, encapsulation efficiency, productivity of VP micelles were investigated by UV.
Results:
The drug loading content and particle size of VP micelles were 20.35% and 118.3 nm, respectively.
Conclusion:
The technology of VP micelles prepared by thin-film hydration method is practical and simple. It's valuable to be further studied.

