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A common polymorphism of the MCT1 gene and athletic performance
Olga N Fedotovskaya1, Leysan J Mustafina, Daniil V Popov
1Sports Genetics Laboratory, St Petersburg Research Inst of Physical Culture, St Petersburg, Russia.
Summary
The monocarboxylate transporter 1 (MCT1) gene A1470T polymorphism is linked to endurance athlete status. This genetic variation also influences blood lactate levels following intense exercise in athletes.
Area of Science:
- Exercise Physiology
- Human Genetics
- Molecular Biology
Background:
- Monocarboxylate transporter 1 (MCT1) facilitates lactate transport into myocytes for oxidation in skeletal muscle.
- The A1470T polymorphism (rs1049434) in the MCT1 gene has been associated with varying lactate transport rates in human skeletal muscles.
Purpose of the Study:
- To compare genotype and allele frequencies of the MCT1 gene A1470T polymorphism between Russian athletes and nonathletic controls.
- To investigate the association of this polymorphism with maximal oxygen consumption and maximal lactate concentration in rowers.
Main Methods:
- Genotyping for the MCT1 A1470T polymorphism was conducted using the PCR-RFLP method.
- Physiological parameters, including maximal oxygen consumption and lactate concentration, were measured in 79 elite Russian rowers during an incremental rowing ergometer test.
Main Results:
- Endurance-oriented athletes exhibited significantly higher frequencies of the A allele (71.8% vs 62.5%) and the AA genotype (59.8% vs 39.4%) compared to controls.
- Male rowers with the T allele (AT+TT genotypes) showed higher mean blood lactate concentrations (10.26 ± 1.89 mmol/L) than those with the AA genotype (8.75 ± 1.69 mmol/L).
Conclusions:
- The A1470T polymorphism in the MCT1 gene is significantly associated with endurance athlete status.
- This genetic polymorphism is also linked to elevated blood lactate levels after strenuous exercise, highlighting its role in exercise performance and physiology.
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