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Feasibility of interstitial diffuse optical tomography using cylindrical diffusing fibers for prostate PDT.

Xing Liang1, Ken Kang-Hsin Wang, Timothy C Zhu

  • 1Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, PA 19104, USA.

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|May 1, 2013
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Summary

This study introduces a new diffuse optical tomography (DOT) method using cylindrical diffuse fibers (CDFs) for improved prostate photodynamic therapy (PDT) dosimetry. The novel CDF-DOT approach enhances light dosimetry calculations for interstitial PDT treatments.

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Area of Science:

  • Biomedical Optics
  • Medical Physics
  • Photodynamic Therapy

Background:

  • Interstitial diffuse optical tomography (DOT) is crucial for characterizing optical properties in prostate photodynamic therapy (PDT) dosimetry.
  • Accurate dosimetry is essential for effective PDT treatment and minimizing side effects.

Purpose of the Study:

  • To develop and validate a novel interstitial DOT method using cylindrical diffuse fibers (CDFs) for simultaneous light delivery and optical property measurement.
  • To improve the accuracy of light dosimetry calculations in interstitial PDT.

Main Methods:

  • Developed an interstitial DOT method employing CDFs as light sources for both DOT measurement and PDT treatment.
  • Utilized absolute light fluence per source strength to differentiate absorption and scattering coefficients.
  • Tested the method using a mathematical phantom and a solid prostate phantom with known optical properties.

Main Results:

  • Successfully reconstructed 3D spatial distributions of optical properties in both phantoms.
  • Demonstrated reliable extrapolation of absorption coefficients, with some crosstalk between absorption and scattering properties.
  • Achieved reconstructed light fluence rate agreement within ±10% of measured values, even with suboptimal scattering coefficients.

Conclusions:

  • The proposed interstitial CDF-DOT method enables reliable optical property reconstruction for prostate PDT dosimetry.
  • This technique offers significantly improved light dosimetry calculations, enhancing the efficacy and safety of interstitial PDT.