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ALMA, an editor for large sequence alignments.

S Thirup1, N E Larsen

  • 1Department of Chemistry, Aarhus University, Denmark.

Proteins
|January 1, 1990
PubMed
Summary
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ALMA is a new sequence editor designed for aligning multiple protein, RNA, or DNA sequences. It offers advanced features like collective sequence movement and secondary structure display for efficient bioinformatics analysis.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • Multiple sequence alignment is crucial for understanding protein and nucleic acid function.
  • Existing sequence editors have limitations in handling large datasets and diverse input formats.

Purpose of the Study:

  • To introduce ALMA, a novel sequence editor with enhanced capabilities for multiple sequence alignment.
  • To provide researchers with a versatile tool for analyzing protein, RNA, and DNA sequences.

Main Methods:

  • ALMA is a menu-directed, screen-oriented sequence editor.
  • It supports input from various sources, including structure files and databases.
  • Features include similarity and consensus display, collective sequence movement, and secondary structure visualization.

Related Experiment Videos

Main Results:

  • ALMA facilitates efficient alignment of numerous protein, RNA, or DNA sequences.
  • The software offers easy merging of alignments and maintains sequence integrity by storing gaps and sequences separately.
  • Automatic session recovery and interactive manual/automatic alignment are supported.

Conclusions:

  • ALMA provides a powerful and flexible solution for complex multiple sequence alignment tasks.
  • Its advanced features enhance usability and efficiency in bioinformatics research.
  • The separate storage of gaps and sequences optimizes disk space and data integrity.