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Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
Published on: November 4, 2016
Blastic plasmacytoid dendritic cell neoplasm in an elderly woman
H B B Foong1, M Chong, E M Taylor
1Universiti Kuala Lumpur Royal College of Medicine Perak, Department of Medicine, No. 3, Jalan Greentown, Ipoh, Perak 30450 Malaysia. bbfoong@pc.jaring.my.
Abstract:
Blastic plasmacytoid dendritic cell neoplasm (a.k.a. NK cell lymphoma, CD4+CD56+ haematodermic neoplasm) is a rare aggressive tumour that arises from plasmacytoid dendritic cell precursors. We report the first case from Malaysia of a 79-year-old Chinese woman who presented with purpuric plaques and nodules produced by pleomorphic CD4+, CD56+, CD68+, CD123+ and CD303+, but CD2APmononuclear cell infiltrates. Leukemic dissemination occurred and she succumbed to disease without treatment 4 weeks after diagnosis and 9 months after onset of cutaneous disease.