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Updated: May 11, 2026
08:45
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Genetic susceptibility to Candida infections
Sanne P Smeekens1, Frank L van de Veerdonk, Bart Jan Kullberg
1Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity (N4i), Nijmegen, The Netherlands.
EMBO Molecular Medicine
|May 1, 2013
Summary
Genetic variations influence susceptibility to Candida infections. Understanding these genetic factors can improve treatment strategies for fungal diseases in immunocompromised individuals.
Area of Science:
- Medical Mycology
- Immunology
- Human Genetics
Background:
- Candida species are significant fungal pathogens causing mucosal and invasive infections, particularly in immunocompromised individuals.
- Host genetic variation is a key factor determining susceptibility to Candida infections, despite risk factors being present.
- Primary immunodeficiencies (e.g., STAT1, STAT3, CARD9 defects) and common gene polymorphisms are linked to fungal infections.
Purpose of the Study:
- To review the role of host genetic variation in susceptibility to Candida infections.
- To explore the link between genetic factors and the pathogenesis of fungal diseases.
- To discuss the potential for developing novel immunotherapeutic strategies based on genetic insights.
Main Methods:
- Literature review of studies on genetic susceptibility to Candida infections.
- Analysis of genetic defects (monogenic and polymorphisms) associated with fungal infections.
- Synthesis of current knowledge on host-pathogen interactions in candidiasis.
Main Results:
- Specific genetic defects, including STAT1, STAT3, and CARD9 deficiencies, are associated with severe fungal infections.
- Common polymorphisms in immune system genes correlate with conditions like recurrent vulvovaginal candidiasis and candidemia.
- Genetic insights are crucial for understanding disease mechanisms and developing targeted therapies.
Conclusions:
- Host genetic background significantly impacts the risk and outcome of Candida infections.
- Identifying genetic determinants of susceptibility advances our understanding of fungal pathogenesis.
- Knowledge of genetic susceptibility can guide the development of new immunotherapies for fungal diseases.
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