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Related Experiment Video

Updated: May 11, 2026

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

Medial temporal lobe volume predicts elders' everyday memory.

Heather R Bailey¹, Jeffrey M Zacks, David Z Hambrick

¹Washington University in St. Louis, MO 63130, USA. hroth@artsci.wustl.edu

Psychological Science

|May 1, 2013

Summary

This summary is machine-generated.

Brain structure volume, specifically the medial temporal lobes, significantly predicts memory for everyday activities in older adults. This finding is crucial for understanding memory decline in aging and Alzheimer's disease.

Keywords:

aging cognitive neuroscience memory perception

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Published on: October 13, 2016

Area of Science:

Neuroscience
Cognitive Psychology
Gerontology

Background:

Memory deficits are common in healthy aging and Alzheimer's disease.
Medial temporal lobes (MTL) and dorsolateral prefrontal cortex (DLPFC) are implicated in memory and affected by aging and Alzheimer's.

Purpose of the Study:

To investigate if brain structure volume, specifically MTL and DLPFC, predicts everyday memory performance.
To explore the relationship between brain volume, everyday memory, and event segmentation abilities.

Main Methods:

Structural MRI was used to measure brain volumes in cognitively healthy older adults and those with mild Alzheimer's-type dementia.
Participants watched everyday activity movies and completed memory tests.
An event-segmentation task was administered.

Main Results:

Medial temporal lobe volume, but not prefrontal cortex volume, strongly predicted subsequent memory performance.
Medial temporal lobe volume partially mediated the link between memory test performance and event-segmentation task performance.

Conclusions:

Everyday memory relies on event segmentation supported by the medial temporal lobes during perception.
The medial temporal lobes are critical for constructing event representations that influence future memory recall.