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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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[The receptors and entry of measles virus: a review]

Guangwen Lu1, George F Gao, Jinghua Yan

  • 1CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|May 2, 2013
PubMed

Insights

Measles virus uses its hemagglutinin (H) protein to bind cellular receptors like CD46, SLAM, and Nectin-4 for cell entry. Understanding this interaction aids in developing measles virus antivirals and oncolytic therapies.

Area of Science:

  • Virology
  • Molecular Biology
  • Immunology

Background:

  • Measles virus, an enveloped virus with a negative-sense RNA genome, utilizes surface glycoproteins hemagglutinin (H) and fusion (F) proteins for host cell entry.
  • The interaction between the measles virus H protein and cellular receptors is critical for viral infectivity and tissue tropism.

Purpose of the Study:

  • To review the molecular mechanisms by which the measles virus H protein recognizes its cellular receptors.
  • To provide insights for the development of novel antiviral drugs and measles virus-based oncolytic therapies.

Main Methods:

  • Literature review of molecular studies on measles virus H protein-receptor interactions.
  • Analysis of the structural and functional aspects of H protein recognition of CD46, SLAM, and Nectin-4.

Main Results:

  • Three primary cellular receptors for measles virus H protein have been identified: CD46, SLAM, and Nectin-4.
  • Detailed molecular understanding of the binding interfaces and recognition mechanisms between H protein and these receptors.

Conclusions:

  • The specific recognition of cellular receptors by measles virus H protein is a key determinant of viral infection.
  • Elucidating these molecular interactions is crucial for advancing antiviral drug design and measles virus-based oncolytic treatments.

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