[Methodology of clinical studies of myorelaxants]

Myorelaxants, a specific pharmacologic group, are often prescribed. However, for many molecules, therapeutic trial methodology is not adapted. A review of the fundamental aspects of pharmacological trial clearly show a need for diagnosis and inclusion criteria, definition and validation for methods of assessment, analysis of the dose-response curve on term of effectiveness according to the pharmacologic and clinically established rules. Rational prescription of myorelaxants will arise from this principles.