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X-ray structure analysis of a solid solution of milbemycins A3 and A4
E Bizdena1, S Belyakov, M Jure
1a Faculty of Material Science and Applied Chemistry, Riga Technical University , Azenes Str. 14/24, Riga , LV-1007 , Latvia.
Abstract:
Milbemycins A3 and A4 are pharmaceutically and agriculturally useful macrolides isolated from Streptomyces species. The molecular structures of the title compounds were unambiguously established by a single crystal X-ray analysis of the solid solution of both compounds. The crystals present trigonal system, space group P32 with Z = 3, unit cell dimensions: a = 12.2211(4), c = 17.5372(7) Å; V = 2268.4(1) Å(3), μ = 0.082 mm(- 1); d = 1.183 g cm(- 3). An interesting system of intramolecular hydrogen bonds and weak intermolecular CH…O type hydrogen bond was observed in the solid state.
