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Updated: May 11, 2026
10:30
Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
Published on: January 25, 2017
IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase
Lavanya Balakrishnan1, Sowmya Soman, Yatish B Patil
1Institute of Bioinformatics, Bangalore, India.
Cell Communication & Adhesion
|May 2, 2013
Summary
This study manually annotated molecular reactions and interactions of Interleukin-11 (IL-11), creating a centralized resource. The findings aid in identifying therapeutic targets for IL-11-related disorders.
Area of Science:
- Molecular Biology
- Cell Signaling
- Biochemistry
Background:
- Interleukin-11 (IL-11) is a pleiotropic cytokine within the gp130 family.
- IL-11 influences hematopoiesis, adipogenesis, embryo implantation, and trophoblast invasion.
- A centralized, publicly available resource for IL-11 molecular reactions is currently lacking.
Purpose of the Study:
- To manually curate and document molecular reactions and interactions induced by IL-11 from existing literature.
- To establish a comprehensive repository of IL-11 signaling pathways.
- To facilitate the identification of therapeutic targets for IL-11-associated diseases.
Main Methods:
- Manual annotation of molecular reactions and interactions from scientific literature.
- Documentation of protein-protein interactions, enzyme-substrate reactions, translocation events, and activation/inhibition reactions.
- Identification of genes differentially regulated by IL-11 stimulation.
Main Results:
- Annotated 40 unique molecules involved in IL-11 signaling.
- Documented 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/inhibition reactions.
- Identified 23 differentially regulated genes under IL-11 stimulation.
- Data made available in standard exchange formats via the 'NetPath' repository.
Conclusions:
- The curated IL-11 signaling pathway resource provides a centralized documentation of molecular events.
- This resource is expected to aid in the discovery of novel therapeutic targets for IL-11-related disorders.
- The availability of data in standard formats promotes further research and analysis.
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