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Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
Published on: January 12, 2024
Primary intraocular central nervous system lymphoma masquerading as diffuse retinal vasculitis.
Deeksha Katoch1, Reema Bansal, Raje Nijhawan
1Department of Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
BMJ Case Reports
|May 2, 2013
Summary
This case study highlights a rare presentation of ocular lymphoma initially mimicking tuberculosis. Prompt diagnosis and treatment of central nervous system (CNS) lymphoma are crucial for patient outcomes.
Area of Science:
- Ophthalmology
- Neurology
- Oncology
Background:
- Ocular inflammation can present with diverse etiologies, including infectious and neoplastic processes.
- Granulomatous panuveitis, vitritis, and retinal vasculitis are inflammatory ocular conditions requiring thorough investigation.
Observation:
- A 49-year-old woman presented with acute blurred vision and floaters, exhibiting signs of severe ocular inflammation.
- Initial treatment for presumed tuberculosis was ineffective, with persistent ocular inflammation and new subretinal lesions.
- Chorioretinal biopsy confirmed non-Hodgkin's lymphoma, a rare cause of intraocular inflammation.
Findings:
- Intravitreal methotrexate successfully resolved ocular lesions.
- Delayed diagnosis led to the development of central nervous system (CNS) lymphoma with neurological symptoms.
- Brain MRI revealed characteristic lesions in the thalamocapsular region and corpus callosum splenium.
Implications:
- This case underscores the importance of considering lymphoma in refractory or atypical presentations of uveitis.
- Early detection and management of CNS involvement in ocular lymphoma are critical for preventing neurological deficits.
- Multidisciplinary approaches involving ophthalmology, neurology, and oncology are essential for managing complex cases of intraocular and CNS lymphoma.
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