Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics of studies falsely excluded during single-reviewer abstract screening: a meta-epidemiological analysis.

BMC medical research methodology·2026
Same author

How the Leng review defines differentiated patients.

BMJ (Clinical research ed.)·2026
Same author

Risk factors for avoidant/restrictive food intake disorder in children: A systematic review.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Detecting false exclusions in single-reviewer literature screening by using AI tools as secondary reviewers: a study protocol for an evaluation study.

Systematic reviews·2026
Same author

Efficacy of remote care in cataract surgery: systematic review.

Journal of cataract and refractive surgery·2025
Same author

Curriculum Innovations: Teaching Residents About Guideline Development and Cost-Conscious Care: A Mixed-Method Evaluation Study.

Neurology. Education·2025

Related Experiment Video

Updated: May 11, 2026

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
10:50

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging

Published on: June 29, 2013

Garlic for peripheral arterial occlusive disease.

Ruth G Jepson1, Jos Kleijnen, Gillian C Leng

  • 1Department of Nursing and Midwifery, University of Stirling, Stirling, UK. ruth.jepson@stir.ac.uk.

The Cochrane Database of Systematic Reviews
|May 2, 2013
PubMed
Summary

This study found that garlic supplements did not significantly improve walking distance in patients with peripheral arterial occlusive disease. Further research is needed to explore potential benefits of garlic for atherosclerosis risk factors.

More Related Videos

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

Related Experiment Videos

Last Updated: May 11, 2026

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
10:50

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging

Published on: June 29, 2013

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Integrative Medicine

Background:

  • Garlic preparations are commercially available and have been anecdotally linked to improved atherosclerosis risk factors.
  • Peripheral arterial occlusive disease (PAOD) is a condition affecting blood flow in the limbs, often associated with atherosclerosis.

Purpose of the Study:

  • To evaluate the efficacy of dried and non-powdered garlic preparations in treating peripheral arterial occlusive disease.
  • To assess the impact of garlic on objective and subjective measures of disease progression in lower limb atherosclerosis.

Main Methods:

  • A systematic review was conducted, searching databases for randomized controlled trials (RCTs) of garlic therapy in patients with lower limb atherosclerosis.
  • The primary outcomes included objective measures like ankle pressure and treadmill testing, alongside subjective symptom progression.
  • Data extraction and quality assessment were performed independently by two reviewers, with efforts to obtain missing information from trial investigators.

Main Results:

  • One small trial with 78 participants (aged 40-75) and a 12-week follow-up was included.
  • Garlic treatment did not lead to a statistically significant improvement in pain-free walking distance compared to placebo.
  • No significant differences were observed in blood pressure, heart rate, or ankle/brachial pressures; a noticeable garlic odor was reported more frequently in the garlic group.

Conclusions:

  • A single, short-duration trial indicated no statistically significant benefit of garlic for improving walking distance in patients with peripheral arterial occlusive disease.
  • The current evidence does not support the use of garlic for treating peripheral arterial occlusive disease based on walking distance outcomes.