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Intra-articular glucocorticoids for acute gout
Mihir D Wechalekar1, Ophir Vinik, Naomi Schlesinger
1Rheumatology Unit, Repatriation GeneralHospital, Daw Park, Australia. mihir.w@gmail.com.
The Cochrane Database of Systematic Reviews
|May 2, 2013
Summary
Current evidence lacks randomized trials on intra-articular glucocorticoids for acute gout. While effective for osteoarthritis and rheumatoid arthritis, their use in gout requires further investigation, especially when other treatments are contraindicated.
Area of Science:
- Rheumatology
- Clinical Pharmacology
Background:
- Intra-articular glucocorticoids are frequently used for acute gout.
- However, robust evidence supporting their safety and efficacy in this specific condition is limited.
Purpose of the Study:
- To systematically evaluate the safety and efficacy of intra-articular glucocorticoids for treating acute gout.
Main Methods:
- Searched major databases (CENTRAL, MEDLINE, EMBASE) and conference abstracts up to October 2012.
- Included randomized controlled trials (RCTs) and controlled clinical trials (CCTs) comparing intra-articular glucocorticoids to other therapies for acute gout.
- Assessed outcomes including pain, function, inflammation, and adverse events.
Main Results:
- No trials were identified that specifically evaluated the efficacy and safety of intra-articular glucocorticoids for acute gout.
Conclusions:
- There is currently no evidence from randomized trials to support the use of intra-articular glucocorticoids in acute gout.
- Evidence from other conditions suggests potential safety and efficacy, warranting consideration when NSAIDs or colchicine are contraindicated.
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