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Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Autoimmune Disorders01:29

Autoimmune Disorders

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Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...

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Related Experiment Video

Updated: May 11, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Addison's disease.

Soumya Brata Sarkar1, Subrata Sarkar, Supratim Ghosh

  • 1Department of Oral Medicine and Radiology, Gurunanak Institute of Dental Science and Research, Kolkata, India.

Contemporary Clinical Dentistry
|May 2, 2013
PubMed
Summary
This summary is machine-generated.

Addison's disease, a rare endocrine disorder, often presents with early intraoral pigmentation before skin changes. Stress can worsen symptoms, potentially leading to a crisis.

Keywords:
Addison's diseaseadrenoleukodystrophyhemochromatosishyperpigmentationprednisolone

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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
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Last Updated: May 11, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
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Published on: September 15, 2017

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Area of Science:

  • Endocrinology
  • Oral Medicine
  • Pathology

Background:

  • Addison's disease is a rare endocrine disorder affecting the adrenal glands.
  • It presents with diverse systemic and oral manifestations.
  • Pathological processes leading to the disease vary.

Observation:

  • Hyperpigmentation is a classic sign, with intraoral manifestations often preceding dermatological ones.
  • Symptoms typically progress slowly.
  • Acute illness or trauma can precipitate a life-threatening Addisonian crisis.

Findings:

  • This case highlights multiple oral and systemic signs of Addison's disease.
  • The early detection of intraoral pigmentation is crucial for timely diagnosis.
  • Understanding the progression and triggers is vital for patient management.

Implications:

  • Early recognition of oral signs can lead to prompt diagnosis and treatment of Addison's disease.
  • Awareness of potential triggers for crisis is essential for preventing severe outcomes.
  • This case underscores the importance of a comprehensive approach to managing endocrine disorders.