Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac enzyme changes in elderly fallers.

D G Swain1, P G Nightingale, R Gama

  • 1Department of Geriatric Medicine, Sandwell District General Hospital, West Bromwich.

Age and Ageing
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does the wearing of masks change voice and speech parameters?

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2021
Same author

Biotin immunoassay interference: A UK-based prevalence study.

Annals of clinical biochemistry·2020
Same author

Acute pseudogout - Measure serum magnesium.

Annals of clinical biochemistry·2019
Same author

Utility of HbA<sub>1c</sub> assessment in people with diabetes awaiting liver transplantation.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

European and Mediterranean hydroclimate responses to tropical volcanic forcing over the last millennium.

Geophysical research letters·2018
Same author

A 10-year longitudinal follow-up study of a U.K. paediatric transplant population to assess for skin cancer.

The British journal of dermatology·2018

Elderly fallers often show elevated creatine kinase (CK) and aspartate aminotransferase (AST) levels. These enzyme elevations are typically due to the fall itself, not acute myocardial infarction (AMI).

Area of Science:

  • Geriatric Medicine
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Falls are common in the elderly, leading to hospital admissions.
  • Assessing the cause of elevated cardiac enzymes in fallers is clinically important.
  • Distinguishing fall-related enzyme changes from acute myocardial infarction (AMI) is crucial for appropriate management.

Purpose of the Study:

  • To investigate enzyme changes in elderly patients admitted after a fall.
  • To determine if elevated creatine kinase (CK), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) are related to the fall or AMI.
  • To identify factors influencing enzyme levels in fallers.

Main Methods:

  • Prospective study of 270 patients admitted to an acute geriatric unit.

Related Experiment Videos

  • Daily measurement of CK, AST, and LDH for 3 days post-admission in 52 fallers.
  • Comparison of enzyme activities based on time spent on the floor and presence of AMI.

    • Main Results:

    • 52 patients (19%) had fallen prior to admission; 5 (10%) had AMI.
    • In fallers without AMI, CK and AST were significantly higher (p<0.05) in those on the floor >1 hour.
    • Elevated CK and AST were observed in 66% and 40% of fallers without AMI, respectively.
    • No other clinical factors influenced enzyme activities.

    Conclusions:

    • Elevated CK and AST in elderly fallers are likely consequences of the fall itself.
    • Enzyme level elevation is not necessarily indicative of acute myocardial infarction in this population.
    • Time spent on the floor correlates with increased muscle enzyme release post-fall.