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Related Experiment Videos

Cardiac enzyme changes in elderly fallers.

D G Swain1, P G Nightingale, R Gama

  • 1Department of Geriatric Medicine, Sandwell District General Hospital, West Bromwich.

Age and Ageing
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

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Elderly fallers often show elevated creatine kinase (CK) and aspartate aminotransferase (AST) levels. These enzyme elevations are typically due to the fall itself, not acute myocardial infarction (AMI).

Area of Science:

  • Geriatric Medicine
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Falls are common in the elderly, leading to hospital admissions.
  • Assessing the cause of elevated cardiac enzymes in fallers is clinically important.
  • Distinguishing fall-related enzyme changes from acute myocardial infarction (AMI) is crucial for appropriate management.

Purpose of the Study:

  • To investigate enzyme changes in elderly patients admitted after a fall.
  • To determine if elevated creatine kinase (CK), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) are related to the fall or AMI.
  • To identify factors influencing enzyme levels in fallers.

Main Methods:

  • Prospective study of 270 patients admitted to an acute geriatric unit.

Related Experiment Videos

  • Daily measurement of CK, AST, and LDH for 3 days post-admission in 52 fallers.
  • Comparison of enzyme activities based on time spent on the floor and presence of AMI.

    • Main Results:

    • 52 patients (19%) had fallen prior to admission; 5 (10%) had AMI.
    • In fallers without AMI, CK and AST were significantly higher (p<0.05) in those on the floor >1 hour.
    • Elevated CK and AST were observed in 66% and 40% of fallers without AMI, respectively.
    • No other clinical factors influenced enzyme activities.

    Conclusions:

    • Elevated CK and AST in elderly fallers are likely consequences of the fall itself.
    • Enzyme level elevation is not necessarily indicative of acute myocardial infarction in this population.
    • Time spent on the floor correlates with increased muscle enzyme release post-fall.