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Advising patients about obtaining genomic profiles.

Donna T Chen1, Lois L Shepherd

  • 1Center for Biomedical Ethics and Humanities (DTC, LLS), Department of Public Health Sciences (DTC, LLS), Department of Psychiatry and Neurobehavioral Sciences (DTC), and School of Law (LLS), Center for Biomedical Ethics and Humanities, University of Virginia Health System, Charlottesville.

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Physicians must understand genomic medicine to guide patients on genetic testing. Realistic expectations and awareness of risks like privacy loss and discrimination are crucial for informed genetic profiling decisions.

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Area of Science:

  • Genomic Medicine
  • Neurology
  • Bioethics

Background:

  • Physicians, including neurologists, need to understand genomic medicine.
  • Genomic profiling offers potential benefits but also significant challenges.
  • Direct-to-consumer genetic testing is expanding.

Purpose of the Study:

  • To inform neurologists about genomic medicine.
  • To guide physicians in managing patient expectations regarding genetic information.
  • To highlight the ethical considerations and risks associated with genomic profiling.

Main Methods:

  • Review of current advancements in genomic medicine.
  • Discussion of ethical implications and patient counseling strategies.
  • Analysis of potential risks associated with genomic information.

Main Results:

  • Genomic medicine requires physicians to manage patient expectations.
  • Interpretable and clinically useful genetic information can be challenging to obtain.
  • Risks include discrimination, privacy loss, and unintended disclosure obligations.

Conclusions:

  • Neurologists must familiarize themselves with genomic medicine to advise patients.
  • Physicians should facilitate realistic patient expectations about genetic testing.
  • Ethical guidance is essential as genomic profiling becomes more accessible.