Single-institution outcome experience using AlloDerm® as temporary coverage or definitive reconstruction for...

Area of Science:

• Plastic Surgery
• Dermatologic Surgery
• Surgical Oncology

Background:

• Reconstruction after skin cancer excision can be challenging due to limited tissue options or patient factors.
• Acellular dermis (AlloDerm) offers a viable alternative for covering complex defects.

Purpose of the Study:

• To evaluate the experience and outcomes of using AlloDerm for skin and soft tissue defect coverage.
• To assess AlloDerm's efficacy as a temporary or permanent reconstructive option.

Main Methods:

• Retrospective review of 67 patients undergoing AlloDerm reconstruction for skin/soft tissue defects (2006-2012).
• Analysis of clinicopathologic data, postoperative findings, and cosmetic outcomes.
• Evaluation of AlloDerm use for temporary coverage, permanent dressing, and in patients requiring adjuvant radiation.

Main Results:

• Melanoma was the most common diagnosis (67%).
• 85% showed healthy AlloDerm incorporation by the first postoperative visit.
• Cellulitis was the most frequent complication (13%), successfully treated with antibiotics.
• AlloDerm was used temporarily in 64% and permanently in 36% of cases.

Conclusions:

• Acellular dermis (AlloDerm) is a suitable coverage option for complex defects after skin and soft tissue resection.
• AlloDerm can serve as a bridge to definitive reconstruction or as a permanent biologic dressing.
• AlloDerm can be safely used in patients requiring adjuvant radiation therapy without major complications.