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Single-donor fibrin glue for hand burns
J D Stuart1, R F Morgan, J G Kenney
1Plastic Surgical Group, Tucson, AZ.
Annals of Plastic Surgery
|June 1, 1990
Summary
Single-donor fibrin glue aids early excision and grafting by improving graft adherence and survival. This method reduces blood loss and operative time, offering a safe alternative for skin graft procedures.
Area of Science:
- Plastic Surgery
- Wound Healing
- Biomaterials
Background:
- Early tangential excision in burn care can lead to significant blood loss, prolonged surgery, and graft failure due to hematoma.
- Fibrin glue has shown promise for hemostasis and graft adherence, but commercial preparations carry risks of viral transmission.
Purpose of the Study:
- To evaluate the efficacy and safety of single-donor fibrin glue as an adjunct in early excision and split-thickness skin grafting.
Main Methods:
- A single-donor fibrin glue method was applied adjunctively in 16 patients undergoing early excision and grafting (26 hands).
- Graft adherence, take rate, operative time, blood loss, infection, and healing were assessed.
Main Results:
- Achieved an overall graft take of 99% with improved adherence of split-thickness grafts to the recipient bed.
- Observed no negative effects on infection or healing.
- Reduced operative blood loss and improved ease of graft application.
Conclusions:
- Single-donor fibrin glue is a safe and effective adjunct for early excision and grafting.
- It enhances graft survival, adherence, and potentially accelerates healing while minimizing complications.
- This method offers a viable alternative to commercial fibrin sealants with reduced viral transmission risks.