Related Experiment Video
Updated: May 11, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
A randomized trial of platelet transfusions over 30 vs 120 minutes: is there an effect on post-transfusion platelet
1Section on Neonatal-Perinatal Medicine, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. douglas-dannaway@ouhsc.edu
Objective:
To determine whether platelet infusion time affects platelet counts in thrombocytopenic newborns.
Study Design:
This was a prospective randomized control study of 43 platelet transfusions given to newborns. Transfusions were randomized to run over either 30 min or 2 h. Platelet counts taken 30 min and 6 h after transfusion were compared using parametric, nonparametric, Pearson's correlation and logistic regression.
Result:
Changes in platelet counts 30 min and 6 h after transfusion were not different between the groups. Weak but significant negative correlations existed between postmenstrual age and change in platelet count at 30 min (r=-0.33, P=0.04) and 6 h (r=-0.37, P=0.018) after transfusion. There were no differences between the mean blood pressures before and after transfusion in either group.
Conclusion:
Transfusion duration does not affect post-transfusion platelet counts in newborns. Babies of lower postmenstrual age (PMA) may have better responses to platelet transfusions. Finally, platelet transfusions over both durations are well tolerated in neonates.
