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Sympathetic skin response in patients with primary premature ejaculation
1Department of Andrology, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, China.
International Journal of Impotence Research
|May 3, 2013
Summary
Patients with primary premature ejaculation (PPE) show heightened sympathetic nervous system activity. Penile sympathetic skin response (PSSR) indicates this hyperactivity, suggesting a role in PPE
Area of Science:
- Urology
- Neuroscience
- Physiology
Background:
- Premature ejaculation (PE) is a common sexual dysfunction.
- The role of the autonomic nervous system in PE is not fully understood.
Purpose of the Study:
- To investigate sympathetic nervous system function in men with primary premature ejaculation (PPE).
- To determine if sympathetic skin response (SSR) can serve as an objective measure for evaluating PPE.
Main Methods:
- Sympathetic skin response on the penis (PSSR) was measured in 52 men with PPE and 46 controls.
- PSSR latencies and amplitudes were analyzed.
- PSSR waveforms were classified.
Main Results:
- No significant difference in PSSR waveform distribution between PPE patients and controls.
- Significantly shorter PSSR latencies in PPE patients compared to controls (P<0.001).
- Significantly greater PSSR amplitudes in PPE patients compared to controls (P<0.001).
Conclusions:
- Patients with PPE exhibit sympathetic nervous system hyperactivity.
- PSSR is a potential objective tool for assessing sympathetic function in PPE.
- Sympathetic hyperactivity may contribute to the pathophysiology of PPE.
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