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Updated: May 11, 2026
09:44
ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
Published on: January 3, 2025
Changing world of neutrophils
Csaba I Timár1, Akos M Lőrincz, Erzsébet Ligeti
1Department of Physiology, Semmelweis University, Budapest, Tűzoltó u. 37-47, 1094, Hungary.
Pflugers Archiv : European Journal of Physiology
|May 3, 2013
Summary
Neutrophils, or neutrophilic granulocytes, are key immune cells with diverse roles beyond microbial killing. This review highlights their involvement in adaptive immunity, non-immune functions, and novel antibacterial mechanisms like neutrophil extracellular traps (NETs) and extracellular vesicles.
Area of Science:
- Immunology
- Cell Biology
- Microbiology
Background:
- Neutrophilic granulocytes (neutrophils) were traditionally viewed as solely involved in microbial killing.
- Recent research reveals neutrophils actively participate in adaptive immunity initiation and organization.
- Neutrophils also engage in non-immune functions, including hemostasis and atherogenesis.
Purpose of the Study:
- To review the multifaceted roles of neutrophils in immunity and non-immune processes.
- To explore novel antibacterial mechanisms employed by neutrophils, including neutrophil extracellular traps (NETs).
- To summarize the significance of neutrophil-derived extracellular vesicles in intercellular communication and antimicrobial defense.
Main Methods:
- Literature review of recent studies on neutrophil function.
- Analysis of research on neutrophil extracellular traps (NETs).
- Review of studies investigating neutrophil-derived extracellular vesicles.
Main Results:
- Neutrophils regulate adaptive immunity through cytokine release and immune cell interactions.
- Neutrophil extracellular traps (NETs) prevent microbial dissemination extracellularly.
- Neutrophil-derived extracellular vesicles mediate intercellular communication and possess distinct antibacterial effects.
Conclusions:
- Neutrophils possess a broader functional repertoire than previously understood.
- NETs and neutrophil extracellular vesicles represent significant advancements in understanding neutrophil-mediated immunity.
- Further research into neutrophil extracellular vesicles may reveal new therapeutic strategies.
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