XRCC1 polymorphisms increase bladder cancer risk in Asians: a meta-analysis

Area of Science:

• Genetics
• Oncology
• Molecular Epidemiology

Background:

• Genetic polymorphisms in DNA repair genes, such as X-ray cross complementing group 1 (XRCC1), are implicated in cancer development.
• Previous studies on XRCC1 polymorphisms and bladder cancer risk in Asian populations have yielded inconclusive results.

Purpose of the Study:

• To conduct a meta-analysis investigating the association between XRCC1 Arg194Trp, Arg280His, and Arg399Gln polymorphisms and bladder cancer risk in the Asian population.

Main Methods:

• A systematic literature search was performed on PubMed, EMBASE, and China National Knowledge Infrastructure up to January 2013.
• Nine eligible studies comprising 1,931 bladder cancer cases and 2,192 controls were included.
• Statistical analysis using odd ratios (ORs) and 95% confidence intervals (95% CIs) was employed to assess the association strength.

Main Results:

• The XRCC1 Arg194Trp polymorphism was associated with a significantly increased risk of bladder cancer (allele comparison OR = 1.20; dominant model OR = 1.20).
• The XRCC1 Arg280His polymorphism also showed a significant association with elevated bladder cancer risk (heterozygote comparison OR = 1.87; dominant model OR = 1.75).
• No significant association was found between the XRCC1 Arg399Gln polymorphism and bladder cancer susceptibility.

Conclusions:

• The XRCC1 Arg194Trp and Arg280His polymorphisms are associated with a significantly increased risk of bladder cancer in the Asian population.
• The XRCC1 Arg399Gln polymorphism does not appear to influence bladder cancer susceptibility in this population.
• These findings contribute to understanding the genetic predisposition to bladder cancer in Asians.