Toward an integrated view of psychophysiological time: comment on "Physiologic time: a hypothesis" by West and West

The James-Lange theory of emotion, proposed by William James and Carl Lange in the late 19th century, asserts that emotions are the result of physiological reactions to external stimuli. Contrary to the traditional view, which suggests that emotions directly arise from the perception of stimuli, this theory proposes that emotions occur as a consequence of the body's responses to such stimuli. According to this framework, an emotional experience is a cognitive interpretation of physiological...

The Cannon-Bard theory of emotion, proposed by Walter Cannon and Philip Bard, challenges the notion that emotions are solely the result of physiological responses. Instead, this theory suggests that emotional experiences and physiological arousal occur simultaneously but operate through independent mechanisms. This dual response is initiated by the brain, specifically by the thalamus, which plays a critical role in processing sensory information.
Upon perceiving a stimulus, such as a dangerous...

Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...

The human brain processes information for decision-making using one of two routes: an intuitive system and a rational system (Epstein, 1994; popularized by Kahneman, 2011 as System 1 and System 2, respectively). The intuitive system is quick, impulsive, and operates with minimal effort, relying on emotions or habits to provide cues for what to do next, while the rational system is logical, analytical, deliberate, and methodical. Research in neuropsychology suggests that the brain can only use...

Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...