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Organophosphate poisoning-induced acute renal failure
Yuval Cavari1, Daniel Landau, Shaul Sofer
1Pediatric Intensive Care Unit, Department of Pediatrics A, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel. cavari@bgu.ac.il
Pediatric Emergency Care
|May 4, 2013
Summary
Organophosphate poisoning can cause acute kidney injury and renal failure. Prompt treatment, such as continuous venovenous hemofiltration, can lead to full recovery of kidney function.
Area of Science:
- Toxicology
- Nephrology
- Critical Care Medicine
Background:
- Acute kidney injury (AKI) is a rare complication of organophosphate (OP) poisoning.
- The underlying mechanisms of OP-induced AKI remain poorly understood.
Observation:
- A 17-year-old female ingested chlorpyrifos, an OP insecticide, in a suicide attempt.
- She developed severe AKI progressing to renal failure, requiring renal replacement therapy.
- Treatment with continuous venovenous hemofiltration (CVVH) resulted in complete recovery of renal function.
Findings:
- Organophosphate poisoning can precipitate acute kidney injury and subsequent renal failure.
- Renal function may be reversible with timely and appropriate medical intervention.
- Continuous venovenous hemofiltration is an effective treatment modality for OP-induced renal failure.
Implications:
- Physicians must consider AKI as a potential complication in organophosphate poisoning cases.
- Early recognition and management of renal dysfunction are crucial for favorable outcomes.
- This case highlights the importance of intensive care and renal support in severe OP poisoning.
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