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Updated: May 11, 2026
08:46
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Severe acute post-streptococcal glomerulonephritis in an infant
Jameela A Kari1, Ahmed Bamagai, Sawsan M Jalalah
1Department of Pediatrics, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. jkari@doctors.org.uk
Summary
Acute post-streptococcal glomerulonephritis (APSGN) is rare in children under two. This case highlights APSGN in a 14-month-old with hematuria and nephrotic syndrome, emphasizing its consideration in infants.
Area of Science:
- Pediatrics
- Nephrology
- Infectious Diseases
Background:
- Acute post-streptococcal glomerulonephritis (APSGN) is typically uncommon in children younger than two years old.
- Group A streptococcal pharyngitis (GAS) is a common childhood infection, but can lead to post-infectious complications.
Observation:
- A 14-month-old infant presented with significant hematuria and nephrotic syndrome.
- The clinical presentation followed a confirmed episode of group A streptococcal pharyngitis.
Findings:
- Renal biopsy confirmed the diagnosis of APSGN.
- Treatment with prednisolone resulted in complete resolution of proteinuria and hematuria within eight weeks.
Implications:
- This case underscores the importance of considering APSGN in the differential diagnosis of hematuria and nephrotic syndrome in infants.
- Early recognition and management are crucial for favorable outcomes in pediatric APSGN.
- Further research may explore the specific factors contributing to APSGN in very young children.
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