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Updated: May 11, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid transformation
Maha Arafah1, Shaesta Naseem Zaidi
1Department of Histopathology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia. marafah@hotmail.com
Abstract:
Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a recently described entity in the World Health Organization (WHO) 2004 classification and has a relatively indolent behavior. Sarcomatoid differentiation has been well documented in most histologic variants of renal cell carcinoma and its presence is known to have a worse prognosis. Its occurrence in an otherwise benign MTSCC is extremely rare. Here, we report a unique case of MTSCC in a 64-year-old patient with multiple areas of high-grade spindle cells and large areas of necrosis in it. The patient had a rapidly fatal clinical outcome.
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