Related Experiment Video

Updated: May 11, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Wave intensity analysis in the human coronary circulation in health and disease

Sayan Sen, Ricardo Petraco, Jamil Mayet

  • 1International Centre of Circulatory Health, National Heart and Lung Institute, 59-61 North Wharf Road, London, W2 1LA, UK. sayan.sen@imperial.ac.uk.

Current Cardiology Reviews
|May 7, 2013
PubMed

Insights

Coronary artery hemodynamics differ from systemic circulation due to myocardial effects. Wave intensity analysis uniquely studies coronary blood flow by distinguishing proximal and distal influences.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Hemodynamics

Background:

  • Systemic arterial hemodynamics do not accurately model coronary circulation.
  • Coronary pressure is influenced by both proximal and distal factors due to myocardial activity.
  • Existing models fail to capture the unique pressure-flow relationship in coronary arteries.

Purpose of the Study:

  • To review the principles of wave intensity analysis.
  • To evaluate its application in understanding coronary hemodynamics.
  • To highlight new insights gained in health and disease.

Main Methods:

  • Wave intensity analysis as an investigative tool.
  • Distinguishing simultaneous proximal and distal influences on coronary blood flow.
  • Review of studies utilizing wave intensity analysis in coronary circulation.

Main Results:

  • Wave intensity analysis effectively differentiates proximal and distal pressure-flow dynamics.
  • It provides a suitable framework for studying coronary hemodynamics.
  • Application reveals novel insights into coronary function in various physiological and pathological states.

Conclusions:

  • Wave intensity analysis is essential for accurate coronary hemodynamic assessment.
  • It offers a unique perspective compared to systemic models.
  • This method advances the understanding of coronary artery function and disease.

More Related Videos

Ultrasonic Assessment of Myocardial Microstructure10:53

Ultrasonic Assessment of Myocardial Microstructure

Published on: January 14, 2014

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Circulation01:21

Coronary Circulation

The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...