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Bone Cells and Tissue

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

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Related Experiment Video

Updated: May 11, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Human progenitor cells for bone engineering applications.

G M de Peppo¹, P Thomsen, C Karlsson

¹New York Stem Cell Foundation, New York, NY 10032, USA. gmdepeppo@nyscf.org

Current Molecular Medicine

|May 7, 2013

Summary

This summary is machine-generated.

Human pluripotent stem cells offer a promising solution for bone deficiencies, overcoming limitations of current treatments. These cells provide a valuable source for engineering functional bone substitutes for clinical applications.

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Last Updated: May 11, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration

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Published on: May 25, 2012

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

Area of Science:

Regenerative Medicine
Biomaterials Science
Skeletal Biology

Background:

Growing prevalence of bone deficiencies presents a significant clinical challenge.
Current bone defect treatments face limitations in efficacy and availability.
Cell-based bone engineering emerges as a promising therapeutic avenue.

Purpose of the Study:

To review the human skeleton and the burden of bone deficiencies.
To evaluate limitations of current bone defect treatments.
To explore opportunities in cell-based bone engineering, focusing on progenitor cell sources for clinical applications.

Main Methods:

Comprehensive literature review on human progenitor cell sources for bone engineering.
Analysis of advantages and disadvantages of different progenitor cell types.
Assessment of cell sources for large-scale functional bone substitute construction.

Main Results:

Human pluripotent stem cells are identified as a superior source for progenitor cell derivation.
These cells combine benefits of embryonic and adult stem cells.
Significant potential demonstrated for creating functional bone substitutes.

Conclusions:

Human pluripotent stem cells hold high potential for bone replacement therapies.
They offer a viable solution for addressing limitations in current bone defect treatments.
Cell-based bone engineering using these cells is a promising strategy for clinical applications.