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[Consensus statement on the clinical management of human immunodeficiency virus-associated neurocognitive disorders]
Insights
This consensus document provides clinical recommendations for managing human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND). Early diagnosis and multidisciplinary management are crucial for improving quality of life in patients with HIV-associated neurocognitive disorder.
Area of Science:
- Neuroscience and Infectious Diseases
- Clinical Management of HIV-Associated Neurocognitive Disorder (HAND)
Background:
- HIV-associated neurocognitive disorder (HAND) is highly prevalent and significantly impacts patients' quality of life and daily activities.
- A growing incidence of HAND is anticipated, necessitating updated clinical management strategies.
Framework:
- A consensus document was developed by a multidisciplinary expert panel (GeSIDA and National AIDS Plan).
- Recommendations are based on a comprehensive review of scientific literature up to October 2012.
- Evidence levels (I-III) and recommendation strengths (A-C) were used, following Infectious Disease Society of America criteria.
Implementation:
- The document provides multiple clinical recommendations for managing HAND.
- Includes two graphical algorithms to guide diagnostic and therapeutic strategies.
- Emphasizes a multidisciplinary approach for comprehensive patient care.
Implications:
- Effective diagnostic and therapeutic management of HAND is essential.
- Proactive and multidisciplinary care can mitigate the negative impacts of HAND on patients' lives.
- This consensus document serves as a vital resource for clinicians managing HAND.
Objective:
To develop a consensus document containing clinical recommendations for the management of human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND).
Methods:
We assembled a panel of experts appointed by GeSIDA and the Secretariat of the National AIDS Plan (PNS), including internal medicine physicians with expertise in the field of HIV, neuropsychologists, neurologists and neuroradiologists. Scientific information was reviewed to October 2012 in publications and conference papers. In support of the recommendations using two levels of evidence: the strength of the recommendation in the opinion of the experts (A, B, C) and the level of empirical evidence (I, II, III), two levels based on the criteria of the Infectious Disease Society of America, already used in previous documents GeSIDA/SPNS.
Results:
Multiple recommendations for the clinical management of these disorders are provided, including two graphics algorithms, considering both the diagnostic and possible therapeutic strategies.
Conclusions:
Neurocognitive disorders associated with HIV infection is currently highly prevalent, are associated with a decreased quality of life and daily activities, and given the possibility of occurrence of an increase in the coming years, there is a need to adequately manage these disorders, from a diagnostic as well as therapeutic point of view, and always from a multidisciplinary perspective.
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