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Related Experiment Video

Updated: May 11, 2026

Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers

Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers

Published on: January 24, 2025

Size distribution of microbubbles as a function of shell composition.

Stephen Dicker¹, Michał Mleczko, Georg Schmitz

¹Department of Chemical Engineering, Drexel University, Philadelphia, PA 19104, USA. smd82@drexel.edu

|May 7, 2013

Summary

Microbubble shell composition, specifically polyethylene glycol (PEG) molecular weight and mole fraction, was experimentally altered. Results indicate no significant correlation between these modifications and microbubble size distribution.

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Last Updated: May 11, 2026

Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers

Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers

Published on: January 24, 2025

Area of Science:

Materials Science
Biotechnology
Chemical Engineering

Background:

Microbubbles are essential tools in biomedical applications, including drug delivery and medical imaging.
The physical properties of microbubbles, such as size, are critical for their efficacy.
Controlling microbubble size distribution is a key challenge in their development.

Purpose of the Study:

To investigate the impact of altering polyethylene glycol (PEG) functionalized polymer shell composition on microbubble size.
To determine the relationship between PEG molecular weight, mole fraction, and microbubble diameter.
To establish methods for reproducible microbubble size control.

Main Methods:

Synthesizing microbubbles with varying polyethylene glycol (PEG) mole fractions (1-15%) and molecular weights (1000-5000 g/mole) in their phospholipid monolayer shell.
Utilizing an unbiased image segmentation program written in MATLAB to analyze micrographs and determine microbubble size distribution.
Measuring mean diameter and variance for different shell compositions.

Main Results:

Microbubbles with 5 mol% PEG2000 exhibited a mean diameter of 1.42 μm with a variance of 0.244 μm.
No statistically significant correlation was found between microbubble size distribution and variations in PEG molecular weight or mole fraction for other compositions studied.
All measured size distributions were nearly Gaussian and monomodal.

Conclusions:

The specific composition of 5 mol% PEG2000 in the microbubble shell yields a defined size distribution.
Microbubble size is not significantly influenced by broad ranges of PEG molecular weight or mole fraction in the studied phospholipid monolayer.
Further research may be needed to identify other parameters controlling microbubble size distribution for biomedical applications.