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Cryptogenic sensory polyneuropathy.

Mamatha Pasnoor1, Mazen M Dimachkie, Richard J Barohn

  • 1Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Boulevard, Kansas City, KS 66160, USA. mpasnoor@kumc.edu

Neurologic Clinics
|May 7, 2013
PubMed
Summary
This summary is machine-generated.

Cryptogenic sensory peripheral neuropathy, often diagnosed after other causes are ruled out, typically presents with slow progression and favorable prognosis. Management focuses on pain relief and physical therapy for balance.

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Area of Science:

  • Neurology
  • Clinical Neuroscience

Background:

  • Chronic sensory or sensorimotor polyneuropathy frequently leads to neurological referrals.
  • A significant portion of patients, up to one-third, are diagnosed with cryptogenic sensory peripheral neuropathy after extensive but inconclusive diagnostic evaluations.

Observation:

  • This condition is characterized by slow symptom progression.
  • Clinical examination may reveal subtle weakness in toe flexion and extension.
  • Electrophysiologic testing and histological analyses confirm an axonal neuropathy pattern.

Findings:

  • The underlying cause remains unknown in a substantial number of patients with sensory polyneuropathy.
  • Axonal neuropathy is the confirmed electrophysiologic and histologic finding.

Implications:

  • The prognosis for patients with cryptogenic sensory peripheral neuropathy is generally favorable, with most retaining independent ambulation.
  • Management strategies include patient education, pharmacotherapy for neuropathic pain, and physical therapy for balance.
  • Assistive devices may be occasionally required.