Related Experiment Video
Updated: May 11, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Introducing enteral feeds in the high-risk preterm infant
1National Institute for Health Research Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust and University of Southampton, Southampton, UK.
Establishing enteral nutrition for very preterm infants requires careful management due to gut immaturity. Breast milk is recommended, with gradual increases in volume and fortification to optimize nutrient intake and prevent growth restriction.
Area of Science:
- Neonatalogy
- Pediatric Nutrition
- Gastroenterology
Background:
- Very preterm infants face challenges in nutrient absorption due to immature gut and metabolic functions.
- Parenteral nutrition is crucial in early weeks while the infant gut adapts.
- Imbalances in intestinal function, nutrition, and microbiota can lead to necrotising enterocolitis.
Purpose of the Study:
- To outline strategies for establishing enteral feeding in high-risk, very preterm infants.
- To emphasize the role of breast milk and appropriate fortification in preterm infant nutrition.
- To highlight the importance of optimizing nutrient intake to prevent extrauterine growth restriction.
Main Methods:
- Review of current practices in neonatal nutrition and enteral feeding.
- Discussion of the physiological adaptations of the preterm gut.
- Emphasis on the use of mother's breast milk as the primary nutrition source.
Main Results:
- Early introduction of small enteral feeding volumes is not detrimental.
- Gradual advancement of enteral feeds is tolerated as gut function improves.
- Supplementation and fortification of breast milk are key to meeting nutritional needs.
Conclusions:
- Optimizing enteral feeding, prioritizing breast milk, is essential for preterm infants.
- Careful monitoring and adjustment of feeding regimens can mitigate risks like necrotising enterocolitis.
- Adequate nutrition is vital to minimize extrauterine growth restriction in this vulnerable population.
Related Concept Videos
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Enteral Nutrition I: Orogastric and Nasogastric Feeding
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Drug Delivery: Enteral Route
Drugs in...
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Routes of Drug Administration: Enteral
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Drug Dosing: Infants and Children
