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Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master

Ludmila F M F Cardozo1, Liliana M Pedruzzi, Peter Stenvinkel

  • 1Federal Fluminense University, Graduate Programme in Cardiovascular Sciences, Niterói-RJ, Brazil. ludmila.cardozo@gmail.com

Biochimie
|May 7, 2013
PubMed

Insights

Nuclear factor E2-related factor 2 (Nrf2) protects against diseases linked to oxidative stress. Nutritional compounds can activate Nrf2, offering potential health benefits by modulating antioxidant and anti-inflammatory responses.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Biology

Background:

  • Nuclear factor E2-related factor 2 (Nrf2) is crucial for cellular defense against diseases involving oxidative stress and inflammation, such as cancer, renal, pulmonary, cardiovascular, and neurodegenerative disorders.
  • Nrf2 regulates detoxifying enzymes via the Antioxidant Response Element (ARE), thereby controlling cellular antioxidant and anti-inflammatory activities.

Purpose of the Study:

  • To review key nutritional compounds that activate the Nrf2 pathway.
  • To explore the potential health impacts of Nrf2 modulation by dietary components.

Main Methods:

  • Literature review of recent studies on Nrf2 activators and modulators.
  • Analysis of nutritional compounds affecting the Nrf2-Keap1 system.

Main Results:

  • Several nutritional compounds have demonstrated the ability to modulate the Nrf2-Keap1 system.
  • These compounds show potential in activating Nrf2-mediated cellular protective responses.

Conclusions:

  • Nutritional compounds represent a promising avenue for Nrf2 activation.
  • Further research into these compounds could lead to novel therapeutic strategies for diseases associated with oxidative stress and inflammation.

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